The authors concluded that a liberal transfusion threshold does not decrease the risk of death or cognitive disability at 24 months corrected age.Īssociation of Nonoperative Management Using Antibiotic Therapy vs Laparoscopic Appendectomy With Treatment Success and Disability Days in Children With Uncomplicated Appendicitis There were no statistical differences noted in the rate of death or cognitive impairment between the two groups. Median volume transfused was 40 mL (IQR, 16-73 mL) vs 19 mL (IQR, 0-46 mL) for the liberal and restrictive groups respectively and weekly mean hematocrit was 3 percentage points higher with liberal thresholds.
#Relux motel toledo ohio trial#
The trial enrolled 1013 patients, with 928 patients completing the trial. Transfusion triggers were a hematocrit of 28% for the liberal transfusion group and 21% for the restrictive transfusion group.
This multi-institutional randomized controlled trial was conducted evaluating the outcomes of ELBW infants assigned to a liberal or restrictive transfusion protocol. Recent studies have suggested that a restrictive transfusion threshold in the ELBW infant increases the risk of long -term cognitive impairment. Restrictive transfusion thresholds have been adopted in both adult and pediatric intensive care units. Standardized transfusion thresholds are not established in extremely low birth weight (ELBW) neonates with transfusions provided based upon clinical symptoms. Effects of Liberal vs Restrictive Transfusion Thresholds on Survival and Neurocognitive Outcomes in Extremely Low-Birth-Weight Infants: The ETTNO Randomized Clinical Trialįranz et al.
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